Introduction and objective: Isolation facilities are closed treatment units for patients with only one type of infection. Isolatories are most often established during epidemics or pandemics, usually due to a shortage of hospital beds, especially infectious hospitals. The aim of this study was to present a model isolation room organized in Poland during the COVID-19 pandemic. Material and methods: The analysis of isolation facilities organization was carried out on a group of 74 patients (20-26 years) with COVID-19 with asymptomatic/sparse course staying in the Isolatrorium of the Ministry of Internal Affairs and Administration Hospital (10.04.2020-8.05.2020), not requiring inpatient treatment. The course of infection was analyzed, a model of patient care was created, and the costs of patient care were analyzed. Results: The hospital incurred organizational costs: infrastructure, patient and companion care, waste disposal, medical supplies, personnel costs. Analysis of the costs incurred by the Hospital showed a significant loss. The costs generated during the operation of the Isolatorium exceeded the funding received from the NFZ by 45%. The economic calculation of the project was significantly affected by the cost of leasing additional premises. Conclusions: The creation of an isolation center during pandemic is a proper intervention in support of epidemic operations. Isolatories created and operated by medical entities must have stable public funding. If there is insufficient public payer funding, there will be no interest in running such activities, which could cause a serious problem in the event of future waves of infections.